Rapamycin
نویسندگان
چکیده
منابع مشابه
Rapamycin
Vaccines that generate Ag-specific CD8(+) T-cell responses of appropriate quality, magnitude and duration are highly desirable. The ability of mTOR to regulate CD8(+) T-cell functional differentiation must be exploited for clinical benefit. In a recent paper, we report that varying the regimen of rapamycin administration regulates viral vaccine-induced CD8(+) T-cell responses for tumor immunity...
متن کاملRapamycin.
Purpose of the Study Pulmonary metastasis continues to be the major cause of mortality among human and canine patients with osteosarcoma. A series of investigational agents will be evaluated in dogs with appendicular osteosarcoma with the hopes of identifying new drugs that help dogs live longer after being diagnosed with osteosarcoma. Rapamycin is a drug that may help slow down the progression...
متن کاملRapamycin-mediated FOXO1 inactivation reduces the anticancer efficacy of rapamycin.
BACKGROUND Mammalian target of rapamycin (mTOR) inhibitors such as rapamycin have shown modest effects in cancer therapy due in part to the removal of a negative feedback loop leading to the activation of the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) signaling pathway. In this report, we have investigated the role of FOXO1, a downstream substrate of the PI3K/Akt pathway in the anticancer eff...
متن کاملTarget of Rapamycin
How was it discovered? Rapamycin was discovered on Easter Island in a natural product screen for anti-fungicides and is produced by the soil bacteria, Streptomyces hygroscopicus. The Target of Rapamycin (TOR) was found in the yeast, Saccharomyces cerevisae, in a screen for mutants resistant to the cytostatic effects of the anti-mycotic. Two isoforms of the yeast protein were identified, TOR1 an...
متن کاملRapamycin-induced phosphaturia.
BACKGROUND The mammalian target of rapamycin (mTOR) is known to stimulate a variety of transport mechanisms including the intestinal phosphate transporter NaPi-IIb. The present study was performed to elucidate whether mTOR similarly regulates the major renal tubular phosphate transporter NaPi-IIa. METHODS To this end, NaPi-IIa was expressed in Xenopus oocytes with or without mTOR and phosphat...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2012
ISSN: 2162-402X
DOI: 10.4161/onci.20663